Research at PTRS

Investigator: Lauren M. Jones-Lush, PhD SOM Faculty Profile GPILS Faculty Profile

 

Neurophysiology of Reaching Rehabilitation in Chronic Stroke

We are investigating the cortical mechanisms that underlie recovery of reaching movements in chronic stroke patients undergoing different forms of therapy.

Grant Support

Source: NIH K12RR023250
Title: Time and state dependence of cortical plasticity in robotic-assisted stroke rehabilitation
Principal Investigator: Alan R. Shuldiner, M.D., Scholar: Lauren M. Jones-Lush
Period: 2008-2011

Current Projects

Dr. Jones-Lush uses robotics, transcranial magnetic stimulation (TMS), and functional imaging (fMRI) to study neuroplasticity, and is applying advanced methods in complex systems analysis to problems of motor rehabilitation after stroke.

 

 

Collaborations

George F. Wittenberg, MD, PhD
Associate Professor
Neurology, VA Baltimore GRECC
University of Maryland School of Medicine

Lab Personnel

Dr. Priya Narayanan completed her PhD from the Mechanical Engineering Department at University of Maryland Baltimore County. During the course of her doctoral studies, she worked as a Research Assistant at the Instrumentation and Sensing Laboratory at US Department of Agriculture. She received a Bachelors degree in Aerospace Engineering from Indian Institute of Technology, Madras and a Masters degree in Mechanical and Aerospace Engineering from University of Florida. She had a brief postdoctoral stint at the Hand Research laboratory at University of Pittsburgh Medical Center. Dr. Narayanan is currently working on Robotic control for NeuroRehabilitation for stroke patients and is looking forward to using her skills in instrumentation and controls as well dynamic modeling in biomedical application and contributing towards study of human motor system.

Publications

Peer-reviewed journal articles

• Jones LM, Lee S, Trageser JC, Simons DJ, Keller A. Precise Temporal Responses in Whisker Trigeminal Neurons. J Neurophysiol. 2004 Jul; 92(1):665-8. [Epub 2004 Mar 3]
• Jones LM, Depireux D, Simons DJ, Keller A. Robust Temporal Coding in the Trigeminal System. Science 2004 June 25; 304(5679):1986-9.
• Reich CG, Karson MA, Karnup SV, Jones LM, Alger BE. Regulation of IPSP theta rhythm by muscarinic receptors and endocannabinoids in hippocampus. J Neurophysiol 2005 Dec; 94(6):4290-9.
• Friedman WA, Jones LM, Cramer NP, Kwegyir-Afful EE, Zeigler HP, Keller A. Anticipatory Activity of Motor Cortex in Relation to Rhythmic Whisking. J Neurophysiol 2006 Feb; 95(2):1274-7.
• Jones LM, Kwegir-Afful EE, Keller A. Whisker primary afferents encode temporal frequency of moving gratings. Somatosens Mot Res 2006 March-June; 23(1):45-54.
• Jones LM, Fontanini A, Katz DB. Gustatory processing: a dynamic systems approach. Curr Opin Neurobiol 2006 Aug;16(4):420-8.
• Jones LM, Fontanini A, Sadacca BF, Miller P, Katz DB. Natural stimuli evoke dynamic sequences of states in cortical ensembles. Proc Natl Acad Sci USA 2007 Nov; 104(47):18772-7. * Faculty of 1000 Biology

Abstracts and/or Proceedings

• Society for Neuroscience Annual Meeting 2004, San Diego, CA. “Coding whisker stimuli in primary and second somatosensory cortex”. L.M. Jones, E.E. Kwegyir-Afful, A. Keller, 978.2
• Society for Neuroscience Annual Meeting 2004, San Diego, CA. “Modulation of whisking frequency by motor cortex”. W.A. Friedman, L.M. Jones, E.E. Kwegyir-Afful, A. Keller, 187.5
• Association for Chemoreception Sciences Annual Meeting, 2006, Sarasota, FL. “Ensemble responses of gustatory cortical neurons accurately predict tastant identity”. L.M. Jones, A.F. Fontanini, M.A. Bourjaily, D.B. Katz.
• Association for Chemoreception Sciences Annual Meeting, 2007, Sarasota, FL. “Cortical networks and the processing of tastes”. D.B. Katz, L.M. Jones, A.F. Fontanini.
• Society for Neuroscience Annual Meeting 2007, San Diego, CA. “State encoding of mechanical variables in the rat trigeminal ganglion”. A.S. Kaloti, L.M. Jones, A. Keller, M.J.Z. Hartmann, 403.1
• Society for Neuroscience Annual Meeting 2008, Washington, DC. “Magnetic cortical stimulation and arm movements in a robotic environment”. L.M. Jones-Lush, T.N. Judkins, G.F. Wittenberg, 861.1
• Society for Neuroscience Annual Meeting 2008, Washington, DC. “Motor cortical plasticity induced by robotic training”. T.N. Judkins, L.M. Jones-Lush, G.F. Wittenberg, 861.2